Website outages and system releases

The European Medicines Agency (EMA) makes upgrades to this website and the Clinical Trials Information System (CTIS) from time to time, to improve user experience. 

During these times, CTIS and this website may be temporarily unavailable or not work optimally. 

You can see when we are planning the next outage below. Registered users can also see notice of any planned interruptions in EMA Service Desk. 

Below you can find the full release notes and a list of any outstanding issues and proposed workarounds for these issues. 

Some functionalities within CTIS rely on other systems which are also maintained by EMA. Upgrades and related work on any of these systems can affect CTIS users’ ability to perform some actions. You can see when we are planning the next maintenance on these systems below.

Planned system interruptions

Users are advised to avoid using CTIS or this website during the regular maintenance windows:

  • Tuesdays and Thursdays, from 18:00 to 21:00 Amsterdam time
  • Every first Saturday of the month, from 10:00 to 14:00 Amsterdam time

The time zone used in CTIS is Central European Time (CET). All due dates and deadlines are displayed in CET despite the daylight-saving time change taking place in Europe on 26 March 2023.

If CTIS is unexpectedly down outside of the above downtime windows, users can consult the CTIS User Support Service landing page for further information.

About release notes

These documents outline the latest updates to the CTIS system, including the secure Sponsor and Authority workspaces, and to the Clinical Trials website. Updates may include improvements to existing features and functionality, the addition of new features and functionality and technical improvements.

Release notes February 2024

Release notes January 2024

Release notes October 2023

Release notes February 2023

Release notes January 2022

This document outlines the latest updates to the CTIS system, including the secure Sponsor and Authority workspaces, and to the Clinical Trials website. Updates may include improvements to existing features and functionality, the addition of new features and functionality and technical improvements, such as improvements to system performance. 

Release notes v1.0.0.5 (PDF, in English) 

Support and training

User support service
If you cannot find an answer to your question in the guidance and Q&As, please contact the User support service.
Guidance and Q&As
Find questions and answers on how to use CTIS.
Training on using CTIS
If you cannot find an answer to your question, please consult our training and supporting materials on how to use CTIS.