Website outages and system releases

The European Medicines Agency (EMA) regularly upgrades this website and the Clinical Trials Information System (CTIS), to improve user experience. Information on planned maintenance, release notes and lists of known issues are available below. 

Planned system interruptions

Users are advised to avoid using CTIS or this website during the regular maintenance windows:

  • Tuesdays and Thursdays, from 18:00 to 21:00 Amsterdam time
  • Every first Saturday of the month, from 10:00 to 14:00 Amsterdam time

The time zone used in CTIS is Central European Time (CET). All due dates and deadlines are displayed in CET despite the daylight-saving time change taking place in Europe on 26 March 2023.

Unplanned system interruptions

If CTIS is unexpectedly down outside of the above downtime windows, users can consult EMA's User support Service landing page for further information.

Release notes

These documents outline the latest updates to the CTIS system, including the secure Sponsor and Authority workspaces, and to the Clinical Trials website. Updates may include improvements to existing features and functionality, the addition of new features and functionality and technical improvements.

CTIS Release Notes v1.0.50.0.pdf (PDF, in English), March 2025

CTIS Release Notes public portal v2.2.0.pdf (PDF, in English), March 2025

Lists of known issues and proposed workarounds

These documents outline the issues that sponsor and authority users may encounter when using the CTIS secure workspaces, with possible workarounds.

The Clinical Trials Information System (CTIS) is the online system for the regulatory submission, authorisation and supervision of clinical trials in the European Union and the European Economic Area.

Support and training

User support service
If you cannot find an answer to your question in the guidance and Q&As, please contact the User support service.
Guidance and Q&As
Find questions and answers on how to use CTIS.
Training on using CTIS
If you cannot find an answer to your question, please consult our training and supporting materials on how to use CTIS.